Paula discovers that estrogen receptors are reduced in hypothermia

 Paula noted that people who are aware of the cold often suffer from menstrual cramps and irregular menstruation. found to decrease in volume.

　

From this, it is expected that reducing the decrease in ERβ expression due to low temperatures may lead to the resolution of women's worries. This knowledge will be applied to products launched by POLA.

A survey conducted by the company suggested that people who are aware of the cold are more likely to experience women-specific problems such as menstrual cramps and irregular menstruation more frequently than those who are not aware of the cold.

It is generally known that women's peculiar troubles are caused by short-term and long-term drastic fluctuations in the amount of estrogen, a female hormone. As a factor other than the drastic fluctuations in estrogen levels, this time we focused on ERβ, a receptor that controls the ability to receive estrogen, and studied its relationship with coldness.

In order to investigate the effects of cold on ERβ, normal human dermal fibroblasts were used to evaluate the expression of ERβ at 37°C, which corresponds to the average body temperature of Japanese people, and 35°C, which corresponds to hypothermia. As a result, we found that the expression level of ERβ was significantly decreased at 35°C compared to 37°C.

It was already known that severe fluctuations in estrogen levels affected women's anxieties, but this study newly suggested the possibility that a decrease in ERβ due to cold weather might affect women's peculiar anxieties.