Japan Cosmetics News

 Shiseido utilizes its proprietary "inner and outer skin 3D elastic imaging technology". When the stratum corneum hardens, the mechanical stress applied to the dermis increases when the skin moves due to facial expressions, etc. It was confirmed that the skin gap between the layer and the dermis) progresses. In addition, it was discovered that the active ingredient "pure retinol", which has been shown to be effective in improving wrinkles, has a softening effect on the stratum corneum, revealing that it has a new function to prevent the progression of wrinkles from the surface of the skin to the depths of the skin. made it While pure retinol has a high skin-improving effect, it is easily decomposed by oxygen, heat, light, etc., so in order to fully demonstrate its effect, it is necessary to keep it stable and deliver it to the skin reliably. In the course of over 30 years of research on retinol, the company has developed a proprietary technology called "Shiseid

 Through joint research with Kirin Holdings, FANCL has discovered that "14-dehydroergosterol (14-DHE)" contained in Kirin's "white koji mold" increases the enzyme "arginase 1" involved in skin beautifying functions. It has been announced that the signs of skin aging can be improved by continuous use of a serum containing koji mold extract. This time, as a result of further elucidating the detailed mechanism of the skin beautifying function of "14-DHE" that has been confirmed so far, "14-DHE" increases arginase 1, inhibits glycation damage, and accelerates aging. It was found that suppressing this leads to anti-aging.

 Paula noted that people who are aware of the cold often suffer from menstrual cramps and irregular menstruation. found to decrease in volume. 　 From this, it is expected that reducing the decrease in ERβ expression due to low temperatures may lead to the resolution of women's worries. This knowledge will be applied to products launched by POLA. A survey conducted by the company suggested that people who are aware of the cold are more likely to experience women-specific problems such as menstrual cramps and irregular menstruation more frequently than those who are not aware of the cold. It is generally known that women's peculiar troubles are caused by short-term and long-term drastic fluctuations in the amount of estrogen, a female hormone. As a factor other than the drastic fluctuations in estrogen levels, this time we focused on ERβ, a receptor that controls the ability to receive estrogen, and studied its relationship with coldness. In order to investigate the effects of co