Clinical Evaluation of Anti-Aging Gels Containing EPA and CBD

 We evaluated the effectiveness of an anti-aging gel containing eicosapentaenoic acid (EPA) and cannabidiol (CBD) in preventing and treating skin aging.


Skin aging is a complex process influenced by various factors such as UV radiation, air pollution and malnutrition. This study aimed to evaluate the compatibility and efficacy of EPA and CBD in skin anti-aging by in vitro, ex vivo, and clinical evaluations.

The results showed that EPA enhanced the protective effects of CBD by reducing the secretion of inflammatory substances associated with photoaging, namely prostaglandin E2 (PGE2) and interleukin-8 (IL-8). Histological examination also observed a positive effect of this gel on extracellular matrix (ECM) remodeling after UV irradiation. In clinical studies (33 subjects), this gel demonstrated significant improvement in various signs of aging. A reduction in the area and volume of wrinkles at the corners of the eyes and a reduction in the volume of fine wrinkles were confirmed. The gel also provided a reduction in redness and increased skin hydration and elasticity. Subjects expressed high satisfaction with this gel product.

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