No effect of omega-3 on dry eye

 The Dry Eye Assessment and Management Study (DREAM study), which evaluated the effects of omega-3 supplements in dry eye syndrome, did not show any benefit of omega-3s compared with placebo. In this study, we performed a secondary analysis of data from the DREAM study to examine the association between dry eye syndrome subtypes and omega-3 effects. The DREAM study randomized 535 patients with moderate-to-severe dry eye syndrome to receive omega-3 or placebo and followed them for 1 year. Identify subtypes based on latent profile analysis baseline ocular surface disease index, tear breakdown time (TBUT), anesthetic Schirmer test, corneal and conjunctival staining, and meibomian gland dysfunction (MGD). Generalized linear regression was used to assess the effect of each subtype of omega-3.


As a result, five clinically meaningful subtypes were identified. Subtypes were characterized by sex and race. Omega-3 had no significant effect over placebo in any subtype.

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