Ingestion of prune extract safely improves chronic constipation

 A randomized trial was conducted to investigate the effect of prune juice on chronic constipation.

Laxatives for chronic constipation have problems such as side effects and insufficient efficacy. Therefore, the search for a highly safe natural food treatment is underway instead of drug therapy. In this study, a randomized trial was conducted in 84 Japanese patients (ages 20-75) to investigate the effectiveness of ingesting prune extract, which contains sorbitol, pectin, and polyphenols, on chronic constipation. Subjects took a placebo or 54 grams of prune extract daily for eight weeks. Efficacy was assessed by subjective complaints on the Bristol Stool Form Scale (BSFS) and Gastrointestinal Symptom Rating Scale (GSRS).

As a result, intake of prune extract significantly decreased loose stools and hard stools and increased normal stools, but no increase in slightly soft stools, muddy stools, and watery stools was confirmed. Subjective symptoms of constipation and hard stool improved, and flatulence, diarrhea, watery stool, and the need for urgent defecation did not change. No adverse events or laboratory abnormalities in liver and renal function were observed due to prune intake.

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