Kose promotes "rejuvenation research" with Shinya Yamanaka

 KOSÉ has ​​dispatched a researcher to the Yamanaka Laboratory led by Dr. Shinya Yamanaka, a senior researcher at the Gladstone Institute (San Francisco, California, USA), which is known for world-class medical research, and will work together to promote "rejuvenation research." We agreed to go ahead. Dr. Yamanaka is also the Emeritus Director and Professor of the Center for iPS Cell Research and Application (CiRA), Kyoto University.


By dispatching researchers to the world's top-level laboratory led by Senior Researcher Yamanaka of Gladstone Research Institute, they will learn cutting-edge research approaches and improve the basic research capabilities of the company's research laboratories. In addition, the company has been conducting aging research using iPS cells and aging model cells derived from the same person, which are rare worldwide. We will continue to develop new cosmetics and services that are ahead of the rest.

Gladstone Institute is an independent, not-for-profit life sciences research institute that uses visionary science and technology to address untapped cures that have a profound impact on medicine, the economy, and society. Aiming to overcome the disease.


Founded in 1979 in San Francisco, California, the Institute is a world-leading medical research institute and has partnerships with major academic institutions in the Bay Area, including Stanford University and the University of California, San Francisco and Berkeley. there is Since 2007, Dr. Yamanaka has been leading the laboratory as a senior researcher at Gladstone Laboratories.


In the future, by collaborating with the Yamanaka Laboratory at Gladstone Institute, we will be able to discover and analyze the mechanism of aging changes that has not been elucidated until now by promoting research using aging model cells derived from the same person. Be expected. By clarifying new mechanisms of aging, we will accumulate knowledge about aging and apply it to the development of cosmetics and services that better meet customer needs.

Until now, as part of its "rejuvenation research," Kose has been working on skin aging research by analyzing and evaluating skin fibroblasts collected from the same person over the ages of 36 to 67 and iPS cells made from them. They reported that the reprogramming of differentiated cells to undifferentiated iPS cells restores the length of telomeres (the ends of chromosomes that shorten with each cell division) in all senescent cells.


As another approach, we succeeded in inducing the differentiation of skin fibroblasts into new skin fibroblasts via iPS cells. Reported improvement in quality.

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