Early use of isotretinoin suppresses acne recurrence in children

 In a study of the use of isotretinoin in pediatric acne and its impact on outcomes, 90 children aged 9-18 years with acne (67.8% girls, mean age 13.5 years) were treated with isotretinoin. Clinical evaluations were performed monthly and one of the eligibility criteria included physician visits. Patients were divided according to age into Group A (9-11 years, 30), Group B (12-13 years, 30), and Control Group C (14-18 years, 30).


As a result, groups A and B completed treatment 2 months after confirmation of clinical improvement (mean 3 months). Group C, the control, received treatment at a mean cumulative dose of 135 mg/kg/day. Thirteen in groups A and B received a second acne treatment, using 3.33% oral isotretinoin, 18.33% topical. In group C, all 30 people received a second acne treatment. Acne scars and post-acne hyperpigmentation were reported in 73.33% of Group C. The researchers concluded that early, rational, short-term use of isotretinoin can reduce future acne breakouts and secondary acne symptoms.

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