Risk of hypertension in middle-aged women with high blood PFAS levels

 PFAS is a synthetic chemical that has been pointed out to have the potential to disrupt blood pressure control and is currently undergoing global tightening of regulations. This study investigated the association between PFAS blood levels and the risk of developing hypertension in 1058 non-hypertensive middle-aged women of various races and ethnicities enrolled in the Study of Women's Health Across the Nation (SWAN). did. The survey was followed up from 1999 to 2017.


As a result, the group with the highest baseline serum concentration had a adjusted hazard ratio of 1.42 for perfluorooctanesulfonic acid and 1.47,2- (N-) for linear perfluorooctanoic acid, compared to the group with the lowest serum concentration. It was 1.42 with ethyl-perfluorooctane sulfonamide) acetic acid. In the mixture analysis, women in the highest PFAS concentration group had a hazard ratio of 1.71 compared to the lowest tertile group. Several PFASs have shown a positive association with the development of hypertension. The findings suggest that PFAS may be an underestimated factor in women's risk of cardiovascular disease.

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