Shiseido finds imbalance of immune cells due to aging affects collagen metabolism

 Shiseido has revealed that the balance of two types of macrophages (immune cells) (M1 / M2 balance) is involved in a series of collagen metabolism such as collagen production, decomposition, and removal in photoaged skin. .. Changes in the amount and properties of collagen in the skin due to adverse effects on collagen metabolism may cause a decrease in skin elasticity.

So far, the company has focused on "Inflammaging" in the skin, and the balance of macrophages in the skin (M1 / M2 balance) is disrupted by photoaging, M1 macrophages increase and M2 macrophages decrease. It reveals that it causes aging of dermal fibroblasts.

In the future, by clarifying the relationship between the balance of macrophages, which are one of the immune cells known to be involved in wound healing in the skin, and the aging of the skin due to aging and light, various skin problems of customers Aim to propose a new approach to.

Collagen is said to occupy about 70% of the dermis layer of the skin and is considered to be one of the important factors that determine the morphological characteristics of the skin. Fibroblasts are known as the main cells that produce this collagen, and it is known that photoaging, which progresses under the influence of ultraviolet rays, reduces collagen production by fibroblasts and causes excessive collagen degradation. As a result, the skin loses its elasticity and elasticity, and it is thought that wrinkles and sagging occur. The company has been conducting research in this field focusing on various factors including fibroblasts, and in the exposed part of the skin, the total number of two types of macrophages M1 and M2 does not change with aging, and the balance. Reveals that changes. This time, we focused on the imbalance of macrophages, which was shown to be involved in skin infrastructure aging, and proceeded with research from a new perspective.

It has recently been reported that M1 / ​​M2 balance is important for controlling collagen metabolism in wound healing. Therefore, we examined the effects of M1 and M2 macrophages on collagen production and degradation by fibroblasts. As a result, a correlation was confirmed between M1 / ​​M2 balance and collagen expression in the skin tissue. In addition, it was clarified that when the culture supernatant of M1 macrophages was added to fibroblasts, collagen fibers were significantly reduced by suppressing collagen production and promoting decomposition. In addition, when the culture supernatant of M2 macrophages is added, collagen production is promoted by evaluation using procollagen, which is a precursor of collagen, as an index, as compared with the case where the culture supernatant of M1 macrophages is added.

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