New combination therapy for adult acne is effective

 The results of a randomized trial evaluating the therapeutic effects of low-dose isotretinoin and chemical peels on adult acne were posted online on April 7 in the Journal of Cosmetic Dermatology.

Isotretinoid monotherapy is not effective for adult acne (acne tarda), mainly in the 25-45 age group, and side effects of long-term treatment have been reported. In this study, the efficacy of a combination of oral isotretinoids and topical chemical peels (20% salicylic acid and 10% mandelic acid) was evaluated in a double-blind, randomized, single-center study.

Group A of 58 outpatients of dermatology who received oral isotretinoin once daily for 16 weeks, and Group B of oral isotretinoin once daily for 16 weeks combined with chemical peels every 4 weeks. It was randomized and the effects were compared at baseline and at a 4-week follow-up. Michelson's Acne Severity Index (MASI) and Visual Analog Scale (VAS) were used to assess efficacy.


As a result, combination therapy was significantly more effective than monotherapy. No serious side effects were seen. It was suggested that the combination therapy of oral isotretinoids and topical chemical peels could be used as an effective new therapy for adult acne.

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