Developed "Euglena Extract EX" as a new cosmetic ingredient

 We confirmed the research results showing that Euglena Extract EX promotes the proliferation of human dermal fibroblasts and epidermal keratinocytes and may eliminate aged cells.

Euglena Co., Ltd. announces that it has standardized "Euglena Extract EX" as a new cosmetic ingredient using the microalgae Euglena.

"Euglena Extract EX" is an extract obtained by extracting the components of Euglena from Euglena powder with BG. We are conducting research on the functions of "Euglena Extract EX", which promotes the proliferation of human dermal fibroblasts and epidermal keratinocytes and suggests the possibility of removing aged cells as follows. We are confirming the research results.

Euglena extract EX was added to human dermal fibroblasts and cultured. As a result, it was confirmed that Euglena extract EX significantly promotes the proliferation of human dermal fibroblasts in a concentration-dependent manner as compared with the one without any addition. Proliferation of dermal fibroblasts can be expected to maintain elasticity and elasticity.

Euglena extract EX was confirmed to promote the proliferation of human epidermal keratinized cells

Euglena extract EX was added to human epidermal keratinized cells and cultured. As a result, it was confirmed that Euglena extract EX significantly promotes the proliferation of human epidermal keratinized cells in a concentration-dependent manner as compared with the one without any addition. When the proliferation of epidermal keratinocytes is promoted, turnover can be expected to remove old keratin and maintain skin health.

The GLS-1 gene is said to be a gene required for the survival of senescent cells, but when Euglena extract EX is added to keratinized cells and cultured, GLS-1 is compared with the control cultured without adding anything. Expression was significantly reduced in a concentration-dependent manner, especially in the 5% addition group. Furthermore, treatment with hydrogen peroxide promotes senescence of keratinocytes, and when Euglena extract EX is added and cultured, Euglena extract is used for normal keratinocytes compared to controls cultured without any addition. The addition of EX promoted cell proliferation, but in senescent cells, the addition of Euglena extract EX did not promote cell proliferation, resulting in a significant decrease. These results indicate that Euglena Extract EX may contribute to the removal of senescent cells.

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