Supramolecular salicylic acid peeling confirmed its effect on acne

 A paper examining the effect of supramolecular salicylic acid peeling on acne was published online on January 24th in the "Journal of cosmetic dermatology".

Twenty-four acne patients were treated with 30% supramolecular salicylic acid peeling every two weeks a total of four times to examine the effectiveness of the peeling, the effect on facial sebum secretion and the skin barrier.

As a result, the Global Acne Rating System (GAGS) score declined with peeling. Sebum levels on the nose, chin, left cheek, and right cheek showed a significant improvement with increasing number of peels. Sebum levels in the T zone were improved over those in the U zone. The VISIA index porphyrin score using the VISIA image analysis system also decreased. Results of skin biopsy and immunohistochemical staining also confirmed decreased expression of sterol response element binding protein (SREBP), fatty acid synthase (FAS), and cyclooxygenase 2 (COX2), which are important factors involved in the regulation of sebum metabolism. 

It was confirmed that 30% supramolecular salicylic acid peeling effectively treats acne and reduces facial sebum secretion without damaging the skin barrier. In addition, the decrease in sebum showed a cumulative effect.

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