Focus on "relationship between lack of sleep and skin"! Poster presentation selected as one of the top 10 in the world International Cosmetic Engineers Association (IFSCC) 2021 Cancun Interim Tournament Maruzen Pharmaceuticals

 Growth hormone (GH), as the name implies, is a hormone that promotes the growth of the body. In adults who have passed the growth period, it is involved in maintaining the homeostasis of the body. In the skin, GH acts on skin fibroblasts to stimulate collagen and hyaluronic acid production through insulin-like growth factor (IGF) -1 production. Furthermore, it is involved in cell proliferation and repair through the action of IGF-1 on epidermal keratinocytes, and plays an important role in maintaining healthy and youthful skin.

GH is secreted a lot during deep sleep, but it is known that the amount of GH secreted decreases with "poor quality sleep" such as light sleep and with aging.

Therefore, in order to reproduce the skin with a reduced amount of GH, we established an evaluation method using our original "sleep deprivation model", and even in the situation where the amount of GH is decreased, the function of GH (production of IGF-1). ) Was "boosted" to search for plant extracts that contribute to maintaining healthy skin condition.

GH, which is secreted during deep sleep, plays an important role in skin repair and maintenance of health through the production of IGF-1. On the other hand, it is said that few consumers feel that they are getting enough sleep in terms of both quality and quantity due to the influence of their busy lifestyle. In order to deal with the highly sensitive symptom of deterioration of skin condition due to lack of sleep, we focused on growth hormone and experimentally reproduced "skin with lack of sleep". As a result, we have found a botanical extract that supports the maintenance of health in sleep-deprived skin.


Taking advantage of these findings, Maruzen Pharmaceuticals has conducted a skin physiology study that will lead to improvement of the skin condition of the responsible generation (30s and older) who are prone to sleep deprivation due to work and childcare, and our company has suggested its effectiveness in this study. Cosmetic raw material "Tokinsenka flower extract (brand name: Tokinsenka extract BG-J)" and "Unshuumikan peel extract (brand name: Japanese ism <un"

We will continue to carry out further applied research on "Satsuma mandarin>)".

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