Shiseido Develops "Shape-Shifting HA Technology" to Control the Volume of Hyaluronic Acid

 Hyaluronic acid is a biopolymer with excellent water retention capacity, and is known to exhibit various physiological activities in addition to moisturizing the skin. Since the amount of hyaluronic acid contained in the epidermis decreases with aging, it is important to supply hyaluronic acid to the inside of the skin in order to maintain healthy skin. However, since the molecules of hyaluronic acid are very large and the stratum corneum acts as a strong barrier, it has been extremely difficult to penetrate hyaluronic acid into the skin.


The Shape-Shifting HA technology developed by Shiseido shrinks hyaluronic acid by adding magnesium ions, realizing higher penetration into the stratum corneum compared to normal hyaluronic acid. Furthermore, by adding sodium metaphosphate, which is a kind of chelating agent (a component that can negate the properties of metal ions by blocking the surrounding metal ions), the shrunk hyaluronic acid is reswelled. It was possible to restore the original properties of hyaluronic acid and increase the moisture content of the stratum corneum.

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