Joint paper with POLA Kasei and the University of Tokyo published in academic journal "Cell Reports"

 POLA CHEMICAL INDUSTRIES conducted joint research with the Institute of Industrial Science, the University of Tokyo on the relationship between skin blemishes and nerves, and in 2021 showed the involvement of nerves in blemishes, following the results published in the Journal of Dermatological Science. Recently, we succeeded in elucidating the mechanism, and a paper was published in "Cell Reports," a sister journal of the world-renowned international scientific journal "Cell."


We will continue to pursue innovative research and aim to provide products that provide surprises and excitement.

The title of the paper is "Human Sensory Neurons Modulate Melanocytes Through Secretion of RGMB", and the results will be used to understand localized skin pigmentation such as age spots and develop improvement methods.

It was known that blemishes tend to occur in certain areas of human skin, but the reasons for this were unknown. On the other hand, it was known that sensory nerves existed near pigment cells (melanocytes) that produce the melanin pigment that causes blemishes. However, the functional relationship between the two cell types has been largely unexplored.


As a result of a detailed investigation focusing on the relationship between sensory nerves and melanocytes, it was found that there was more contact between sensory nerves and melanocytes inside spots on human skin compared to areas without spots. When melanocytes were cultured together with sensory neurons made from human iPS cells (induced pluripotent stem cells), they elongated processes more actively and produced more pigment than when cultured alone.

In order to elucidate this mechanism, we comprehensively examined proteins secreted from human iPS cell-derived sensory neurons and found that a protein called RGMB (Repulsive Guidance Molecule B) stimulates melanocyte process outgrowth and pigment production. pinpointed. RGMB also activated the mechanism by which melanocytes release pigment-laden vesicles out of the cells.


From these findings, it was clarified that sensory nerves in human skin activate melanocytes by secreting RGMB.

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