Anti-melanin forming effect of nicotinamide mononucleotide

 Nicotinamide mononucleotide is a component that has been confirmed to have increased energy and lipid metabolism and increased insulin sensitivity in mouse tests, and is expected to have an antiaging effect. In this study, we investigated the effect of nicotinamide mononucleotide on skin pigmentation. It was applied to both young and aged melanocytes and analyzed for melanin production, protein expression, and mRNA levels. In addition, a human skin model was used to examine the effect of nicotinamide mononucleotides on melanin formation in vivo.


As a result, nicotinamide mononucleotide did not show a clear effect on young melanocytes, but a significant decrease in melanin production was observed in aged melanocytes.

Nicotinamide mononucleotides also efficiently reduced melanin production in human skin, including aged melanocytes. Genome-wide analysis shows down-regulation of melanin formation-related cAMP / Wnt signaling in aged melanocytes, showing melanin formation-related protein, tyrosinase (TYR), tyrosinase-related protein (TRP) -1, and TRP-2 forskolin. Down-regulation of induced expression was also confirmed. It has been suggested that nicotinamide mononucleotides are human-friendly antimelanogenic agents that may affect the treatment of age-related hyperpigmentation.

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