Confirmed photoaging inhibitory effect of pearl extract

 Test results to confirm whether pearl oyster extract has a photoaging inhibitory effect were posted online on January 30th in "Chemistry and Biodiversity".

Pearl powder has been recognized and used for health care and cosmetology since BC. However, there are few studies on its photoaging inhibitory effect. In this study, we evaluated the protective effect of pearl extract on UV-induced photoaging in mice. First, amino acid analysis of pearl extract was performed. In addition, different doses of pearl extract gel were topically applied to the shaved back skin area of ​​mice prior to UV irradiation and used for skin physiologic and histological analysis, antioxidant enzyme and inflammatory factor tests. The anti-photoaging effect of the pearl extract gel was evaluated.

As a result, it was suggested that the pearl extract gel contains 14 kinds of amino acids and can be expected to suppress wrinkles, sagging, thickness and dryness of UV-stimulated skin. In addition, the pearl extract gel upregulates the activity of CAT, GSH-Px, SOD, lowers MDA levels, IL-1 𝛽, IL-6, PGE 2, TNF-𝛼, and COX- in UV-irradiated mice. It was observed to suppress the production of 2. The therapeutic effect of the high-dose pearl extract gel-administered group was superior to that of the positive control (vitamin E-administered group). This study demonstrated the underlying mechanism of pearl extract gel against UV-stimulated photoaging and showed the potential of pearl extract gel PEG to be used in photoprotective agents and cosmetics.

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