Confirmed "cell migration activating effect" in "pearl citrus" extract from Kumamoto

 Reharukan Pharmaceutical Co., Ltd. announced on September 16 that it has confirmed the "migratory * activation" effect of fibroblasts in the extract extracted from the skin of the citrus "pearl citrus", which is mainly produced in Kumamoto prefecture.

This means "movement of cells that produce collagen", and this action is expected to distribute "uniform collagen production" in the human body, suggesting that it can be applied to applied research for wrinkle prevention effects. Was done.

"Fibroblasts" that produce collagen have the function of moving to a place where the density of cells is low (migratory).

However, it has been reported that this force also declines with age, and the company said, "'The density of fibroblasts is uneven' means that'collagen is not produced (produced where there are no cells). The distribution of collagen will be uneven.) ”

Therefore, the company sought the possibility of enhancing "cell migration", which is the key to collagen production, from the extract extracted from "pearl citrus", a research material aimed at "local production for local consumption".

In the evaluation of plants having cell migration, the expression level of cell migration-related factors (SPP1 / CD44v6) was used as an index. As a result of the examination, it was found that citrus fruits have a tendency to be active.

Further detailed examination found the most significant effect on the extract extracted from "pearl citrus".

In addition, in the verification using fibroblasts in the migration property of pearl citrus extract, it was confirmed that the migration activity increases in proportion to the concentration.

The company commented on this, saying, "Because it contributes to wrinkles in areas where collagen is deficient, the effect of pearl citrus extract makes the cell density uniform. ) It suggested that the cells should be distributed in a well-balanced manner and that the environment should be easy for collagen to be produced, "and" prevention of wrinkles due to collagen deficiency. "

In the future, based on the results of this research, we aim to apply it to original raw materials that approach skin problems such as skin firmness and lack of elasticity.

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